effect of amyloid β- peptide on passive avoidance learning in rats: a behavioral study

conclusions these data suggest that single bilateral microinjection of aβ (25-35) could impair memory and can be used as an ad model in wistar rats. results the results showed that aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. background alzheimer's disease (ad) is the most common form of dementia that leads to neurotoxicity. amyloid β-peptide (aβ) has a pivotal role in the pathogenesis of ad. objective given the contradictory results of aβ (25-35) on the memory, in the present study we have examined the effect of aβ - induced memory impairment. materials and methods wistar male rats received an intrahippocampal (ihp) injection of aβ (25-35).the learning function in the rats was examined by the passive avoidance task.